13 results
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm

Suspected TMA: Unexplained thrombocytopenia + MAHA
- Differential Diagnosis ... TMA: Unexplained thrombocytopenia ... hemoglobin/hemosiderin, Hepatic ... hemosiderin • PT/aPTT ... Management #Algorithm #hematology
4T Score for Heparin-Induced Thrombocytopenia

Interpretation of the 4T score:
0-3 points:  Low probability (<<1%)
  -
Thrombocytopenia ... - No further workup ... HeparinInduced #Thrombocytopenia ... #Diagnosis #Criteria ... #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
- Differential Diagnosis ... and Workup History ... cases: INR/PT, aPTT ... #Causes #Workup ... #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
dysfunction (25%) • Hepatic ... 100mg/dL) - Heparin ... INR < 2.3 - APTT ... #Coagulation #diagnosis ... treatment #management #hematology
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
unfractionated heparin ... . heparin contamination ... thrombin inhibitors, heparin ... Prolonged #Causes #diagnosis ... #differential #hematology
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Differential Diagnosis ... . heparin contamination ... thrombin inhibitors, heparin ... Prolonged #Causes #diagnosis ... #differential #hematology
Approach to the Hypercoagulable State
Arterial thromboembolism
→ Cardiac rhythm monitoring, Echocardiogram, Vascular imaging
→ Test for APS, particularly
• Provoked (e.g ... - No other workup ... screening, CBC, aPTT ... #hematology #diagnosis ... #algorithm #hematology
Summary of Coagulation Deficiencies
Inherited:
 • Hemophilia A - Deficiency of Factor VIII
 • Hemophilia B -
Malabsorption (e.g ... Medications - Heparin ... Deficiencies #Summary #table ... #comparison #diagnosis ... #hematology #deficiency
Inherited Qualitative Platelet Defects
Bernard-Soulier Syndrome
 • Defect of adhesion due to a lack of GP Ib/IX/V
receptor] • Thrombocytopenia ... sensorineural hearing ... Defects #comparison #table ... #differential #diagnosis ... #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
for Thrombotic Thrombocytopenic ... activity is the diagnostic ... available for rapid diagnosis ... performed PT, PTT ... #Workup #Hematology