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diagnosis causes sle activation algorithm arteritis arthritis atlas bloodcell disease disorders elevatedmcv erythematosus extravascular gca giantcell hcq hemolysis hemolytic hydroxychloroquine
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
(usually IgG) (e.g ... . lupus, CLL, lymphoma ... (usually IgM) (e.g ... deficiencies (e.g ... #diagnosis #hematology
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased Heme Synthesis or
Volume (MCV) - Differential ... Iron Deficiency (Eg ... Other • e.g ... HgbE, HgbC, etc. ... Algorithm #Causes #Hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Chemotherapy (e.g ... Liver disease, Etc ... valve induced, Etc ... RBC #Morphology #differential ... #diagnosis #hematology
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
Special cases (e.g ... Measurement #SLE #rheumatology ... #pharmacology # ... levels #lupus #management
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Platelet Disorders - Differential ... Diagnosis and Workup ... function test, ANA (e.g ... changes), high MCV anemia ... #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
underlying disease (eg ... • Infection (eg ... with leukopenia, anemia ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... • Malignancy (e.g ... Endocrine disorders (e.g ... lymphopenia, low PLT • Anemia ... Erythematosus #Diagnosis #Rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... joint • Systemic lupus ... inflammatory disease (e.g ... Chemistry profile (e.g ... diagnosis #testing #Rheumatology
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
not be subtle e.g ... very remarkable w/differential ... E.g. 80 yo ESR cutoff ... systemic complaints- anemia ... them, but urgent rheumatology
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