10 results
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
) Cancer-treatment ... inducers #inhibitors #Chemotherapy ... #Oncology #Hematology ... #Interactions #Table ... #Pharmacology
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis.

Currently, edoxaban and rivaroxaban are the only
stratification algorithm ... for the treatment ... #Cancer #Algorithm ... Anticoagulation #Management ... #Hematology #Oncology
DOAC Reversal
Emergency surgery or urgent procedure
Stop anticoagulant treatment; volume resuscitation and transfusion as needed
Antidotes:
 • Apixaban,
DOAC Reversal Emergency ... anticoagulant treatment ... not available #DOAC ... anticoagulant #hematology ... #management #pharmacology
Treatment algorithm for VTE in Malignancy

(A) Suggested treatment algorithm for symptomatic and incidental DVT or PE
Treatment algorithm ... DOAC, direct oral ... #DOAC #VTE #Malignancy ... Anticoagulation #Management ... #Hematology #Oncology
Managing warfarin INR

Warfarin dosage must be individualized according to the patient's response to the drug, and
#management #algorithm ... #pharmacology # ... treatment #medications ... #table #pharmacotherapy ... decisionaid #cardiology #hematology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
organ damage • Treatment ... - Cytotoxic chemotherapy ... unless worrisome EKG ... TLS #diagnosis #management ... #hematology
Mycosis Fungoides - Therapy Escalation

Later stage MF requires collaboration with an oncologist

Topical Steroids 
Nitrogen Mustard 
Bexarotene
Mogamulizumab Chemotherapy ... Doxil, ICE, CHOP, etc ... Escalation #Therapy #Management ... #Treatment #Dermatology
SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
and lower jaw Treatment ... antiinflammatory properties e.g ... Tetracyclines etc ... #diagnosis #management ... #Dermatology
It is important to recognize Acute Decompensated Heart Failure (ADHF) as more than just simply a
ECG is vital while ... #differential #algorithm ... #management #cardiology ... #treatment #table ... icu #clinical #pharmacology
Essential Thrombocythemia (ET)
ET is a chronic myeloproliferative neoplasm. Most cases are related to mutations that affect
Treatment is ... • Treatment algorithms ... Thrombocythemia #ET #hematology ... #diagnosis #management ... #hematology