11 results
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophil Disorders ... evaluation or workup ... for specific symptoms ... #Algorithm #Differential ... #diagnosis #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
- Differential ... Diagnosis and Workup ... pylori test (GI symptoms ... #Differential # ... #Workup #hematology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Pathophysiology ... Signs and Symptoms ... Diagnosis: • ... bile ducts Differential ... #workup #hepatology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
lymphoproliferative disorder ... infection, autoimmune disorder ... younger pts) Differential ... IgM Includes Disorders ... hemolytic #anemia #hematology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
- Differential ... Diagnosis Algorithm ... pattern of spread, B symptoms ... Classification #pathophysiology ... #Hematology #Diagnosis
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
ATRA treatment Pathophysiology ... : >3 symptoms, or ... initiation • Differential ... fluid overload, PCC ... #management #hematology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Diagnosis: • ANCA-associated ... Malignancy (e.g. hematologic ... Induced Lupus: • Symptoms ... Erythematosus #Diagnosis
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... ingestion • B symptoms ... Hodgkin Lymphoma Workup ... Immunohistochemical studies (to differentiate ... classification #hematology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... age 70 years Symptoms ... blood count with differential ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
Albumin > 4) Work-up ... Connective tissue disorders ... gastric tumors • Hematology ... Gap #ProteinGap #differential ... #diagnosis #hematology