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diagnosis hemolysis rheumatology workup autoimmune bandemia causes cell central erythematosus extravascular intravascular lupus maculopapular myopathy myositis neutrophil oncology pathophysiology plasmacytoma
Maculopapular Rashes - THE ALGORITHMIC APPROACH The term maculopapule is a portmanteau, a combination of macule and
Maculopapular Rashes - THE ALGORITHMIC ... require emergent evaluation ... #Diagnosis #Dermatology ... #Algorithm #Central ... #Peripheral #Differential
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... HELLP - Grafts, Valves ... Drug-associated, PCH ... Dehydrogenase ↑ - Peripheral ... #Diagnosis #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Diagnosis Algorithm ... elliptocytosis - RBC ... Cold AIHA • PCH ... Prosthetic heart valves ... #Causes #Hematology
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
approximately 5-10% of peripheral ... appreciate the value ... count on initial evaluation ... #Bandemia #differential ... #CBC #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory Evaluation ... If the value is ... the range of Peripheral ... count and differential ... Diagnosis #Workup #Hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Malignancy (e.g. hematologic ... Arthritis: • Joint pain ... Mononeuritis Multiplex • Peripheral ... titers > 1:80 • CBC
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
presents with pain ... ridging around the periphery ... Diagnostic Evaluation ... • CBC + diff • ... Diagnosis #Workup #Hematology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis - Differential ... Aldolase levels • EMG ... Symptoms: • Gottron rash ... Other Diseases: • PBC ... #differential #
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