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diagnosis hepatology algorithm causes rheumatology aih injury lfts management acute antibodies associations autoantibodies chemistry cirrhosis common comparison cvid diseases erythematosus
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Injury - Differential ... Other: NAFLD, Autoimmune ... , 1° PSC, Cystic ... #Injury #Differential ... Acute #algorithm #hepatology
Common Etiologies of Cirrhosis Inflammation - Hepatitis B (15 percent) - Hepatitis C (47 percent) - Schistosomiasis
Schistosomiasis - Autoimmune ... Nonalcoholic fatty liver ... heart failure (chronic ... #Diagnosis #Differential ... #Hepatology #Cirrhosis
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 Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... • Autoimmune: ... Autoimmune hepatitis ... • NASH, Chronic ... #differential #
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
common in SLE, autoimmune ... hepatitis Anti-CCP ... Dermatomyositis Anti-LKM (liver ... biliary cirrhosis (PBC ... Endomyseal antibody (EMA
Clinical Diagnosis of Autoimmune Hepatitis - Onset of jaundice within prior 8 weeks - Ongoing consumption
Clinical Diagnosis ... of Autoimmune Hepatitis ... >1.5, and both values ... ) or metabolic liver ... #Hepatology #AIH
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential ... • Ischemia • Autoimmune ... • Cholestatic disease ... • Alcoholic hepatitis
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Renal Failure • Liver ... Neoplastic / Hematologic ... Epstein-Barr Virus • Hepatitis ... • HIV Autoimmune ... Obstructive Pulmonary Disease
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
HELLP - Grafts, Valves ... Membrane): - Autoimmune ... Drug-associated, PCH ... Defects, Drugs, Liver ... #Diagnosis #hematology
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
Autoimmune Hepatitis ... from subclinical disease ... to acute liver ... - Symptoms of chronic ... reported (eg AIH-PBC
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs R-value ... of cholestatic disease ... disease: > 2 ... • NASH, Chronic ... chemistry #diagnosis #differential
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