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diagnosis hepatology rheumatology hepatitis agglutinin algorithm anemia antibodies associations causes cold diseases erythematosus hemolysis hemolytic lfts liverenzymes lupus management myopathy
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and ... common in SLE, autoimmune ... Dermatomyositis Anti-LKM (liver ... biliary cirrhosis (PBC ... Endomyseal antibody (EMA
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
HELLP - Grafts, Valves ... Membrane): - Autoimmune ... Drug-associated, PCH ... Defects, Drugs, Liver ... #Diagnosis #hematology
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
Autoimmune Hepatitis ... from subclinical disease ... to acute liver ... been reported (eg AIH-PBC ... and Titers of Autoantibodies
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential ... • Ischemia • Autoimmune ... • Drugs • AIH ... • Cholestatic disease
Clinical Diagnosis of Autoimmune Hepatitis - Onset of jaundice within prior 8 weeks - Ongoing consumption
Clinical Diagnosis ... of Autoimmune Hepatitis ... >1.5, and both values ... ) or metabolic liver ... #AIH
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
women • 15% of AIHA ... Viral infection, autoimmune ... Viral Infection Clinical ... pts) Differential ... hemolytic #anemia #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... • Anti-Ro/SSA autoantibodies ... permanent alopecia Differential ... • Non-autoimmune ... : • AIHA 10% •
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
- Differential ... Aldolase levels • EMG ... Mechanic's hands Autoantibodies ... : • PBC, autoimmune ... #differential #
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