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diagnosis causes hepatology algorithm hemolysis acidosis autoimmune chemistry classification elevation erythematosus extravascular gap globulin hepatitis interpretation intravascular lactate lactic liverenzymes
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... HELLP - Grafts, Valves ... Drug-associated, PCH ... Defects, Drugs, Liver ... #Diagnosis #hematology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential ... • Drugs • AIH ... • Cholestatic disease ... • Others #LFTs
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Intravascular Hemolysis - Differential ... • PCH ... anemia • Acute ... Prosthetic heart valves ... Algorithm #Causes #Hematology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... R-value: Serum ... disease: > 2 ... chemistry #diagnosis #differential ... #LFTs #RValue #
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
from subclinical disease ... to acute liver ... hepatocellular pattern of liver ... been reported (eg AIH-PBC ... regarding need for treatment
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: • Acute ... permanent alopecia Differential ... Pleural effusions • Acute ... : • AIHA 10% • ... Erythematosus #Diagnosis #Rheumatology
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Lactic Acidosis - Differential ... to bolus these values ... presentations and disease ... cardiac output - Acute ... peritonitis - Acute
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Sarcoidosis) • Liver ... gastric tumors • Hematology ... inflammation (acute ... Gap #ProteinGap #differential ... #diagnosis #hematology
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