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diagnosis causes management algorithm blood generalized primary product reactions rheumatology secondary systemic arterial biliary cholangitis cirrhosis classification dermatologic elevation embolism
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Pruritus - Generalized ... Diabetes Mellitus Liver ... • Cholestatic liver ... disease Creatinine ... #generalized #dermatology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Dermatologic Manifestations ... GPA causes disease ... associated with pruritus ... reticularis Differential ... #dermatology #rash
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Pruritus - No Primary ... Skin Lesion - Differential ... • Cholestatic liver ... disease Creatinine ... #generalized #dermatology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
cholestasis → Cirrhosis/Liver ... asymptomatic • Pruritus ... Examination: • Skin ... or higher • Liver ... bile ducts Differential
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... HELLP - Grafts, Valves ... Drug-associated, PCH ... Defects, Drugs, Liver ... #Diagnosis #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... purple, hemorrhagic skin ... deficiency • Liver ... #Diagnosis #hematology ... #nonpalpable #dermatology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Myeloproliferative disease ... Testosterone - Coumadin skin ... Syndrome, Ischemic Liver ... Vasculitis • Injury ... pathophysiology #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
gammopathy, and skin ... Sarcoidosis) • Liver ... gastric tumors • Hematology ... #ProteinGap #differential ... #diagnosis #hematology
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
- Differential ... to bolus these values ... presentations and disease ... or renal injury ... Injury: • Reduced
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... Alpha & Mu) Skin ... Pseudohyponatremia • ↓anion gap ... Paraproteinemias #Hematology ... #Monoclonal #Differential
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