15 results
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury
Hepatocellular Liver Injury
 • AST/ALT elevation
Liver Enzymes (LFTs ... Injury • AST/ALT elevation ... • R value = (ALT ... #Cholestatic #Transaminitis ... #diagnosis #differential
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
- Differential ... Algorithm ALP: - Enzymes ... disturbance (obstructed liver ... Highest • Bone • Liver ... #Differential #
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
HELLP - Grafts, Valves ... Drug-associated, PCH ... Defects, Drugs, Liver ... , Spiders - Enzyme ... #Diagnosis #hematology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
- Differential ... Bilirubin - +/- elevation ... Enzyme Elevation ... injury #hepatitis #differential ... diagnosis #algorithm #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs R-value ... disease: > 2 ... Enzyme Elevation ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... - Differential ... • Cholestatic disease ... Bile Ducts • PSC ... Others #LFTs #Hepatology
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
Liver Disease in ... to 10-20-fold elevation ... enzymes, and Low ... #Disease #Pregnancy ... hepatitis #comparison #differential
Non-alcoholic fatty liver disease algorithm.
 
For those patients with NAFLD or liver disease of unknown aetiology,
fibrosis score with values ... markers such as ELF ... force impulse; ELF ... 4, fibrosis-4; HCC ... Referral #Management #Hepatology
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
the magnitude of enzyme ... elevation and clinical ... disease; T2DM, ... #Liver #Enzymes ... #Differential #
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework

LDH is a cytoplasmic enzyme present in tissues throughout
Dehydrogenase (LDH) - Differential ... a cytoplasmic enzyme ... RBCs, muscle, liver ... - Prosthetic valves ... Idiosyncratic LDH Elevation