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diagnosis algorithm causes hematology injury transaminitis acute cholangitis elevated elevation lactate mass rheumatology workup abnormal acidosis alkaline alp antibodies arterial
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Chronic - ongoing ↑ LFTs ... disease 6-9 mo ... Calculate R-Value ... Idiosyncratic #differential ... gastroenterology #hepatology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
ALP) Elevation - Differential ... Highest • Bone • Liver ... Cholestasis - Drugs ... - Primary biliary ... Diagnosis #Algorithm #hepatology
Liver Mass Differential Diagnosis Solid: • Benign: Hepatic Hemangioma, Focal nodular hyperplasia, Hepatocellular adenoma, Regenerative nodules •
Liver Mass Differential ... disease, Biliary ... Cystadenocarcinoma, Primary ... #Mass #Differential ... #Diagnosis #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential ... • Cholestatic disease ... • Others #LFTs ... #Hepatology #LiverEnzymes
Causes of Severe Acute Liver Injury - Ichemic hepatitis - Acute biliary obstruction - Drug-Induced liver
obstruction - Drug-Induced ... hepatitis - Wilson disease ... Hemochromatosis - Primary ... Acute #Causes #Differential ... #Hepatology #Diagnosis
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... HELLP - Grafts, Valves ... , PCH, Evans Syndrome ... , Liver Disease, ... #Diagnosis #hematology
Liver Mass - Differential Diagnosis Algorithm Cystic: • Benign - Simple: Simple
Liver Mass - Differential ... Disease, Caroli's ... Malignant - primary ... - HCC, CCA, HB ... Algorithm #Causes #Hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... 15X ULN - Drugs ... Burak @kwburak #LFTs ... Algorithm #diagnosis #hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Injury - Differential ... , Recreational Drugs ... , 1° PSC, Cystic ... #Injury #Differential ... Acute #algorithm #hepatology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
cholestasis → Cirrhosis/Liver ... or higher • Liver ... bile ducts Differential ... , Sarcoidosis, Drug-induced ... diagnosis #workup #hepatology
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