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hemolysis neurology rheumatology agglutinin algorithm anemia causes cold disease erythematosus extravascular gravis hemolytic intravascular lupus management myasthenia myopathy myositis sle
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Diagnosis Framework ... HELLP - Grafts, Valves ... Membrane): - Autoimmune ... Drug-associated, PCH ... #Diagnosis #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Diagnosis Algorithm ... Cold AIHA • Alloimmune ... Cold AIHA • PCH ... Prosthetic heart valves ... #Causes #Hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Agglutinin Syndrome (CAS ... Viral infection, autoimmune ... CLL (older) • Autoimmune ... younger pts) Differential ... hemolytic #anemia #hematology
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
Weakness - Differential ... Diagnosis Framework ... pulmonary etc) • CNS ... necrotizing myopathy • Autoimmune ... #Diagnosis #neurology
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
Myasthenia Gravis is an autoimmune ... Hodgkin lymphoma - Autoimmune ... life-threatening Differential ... myasthenia Diagnosis ... Serologic and EMG
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Diagnosis: • ANCA-associated ... disease • Non-autoimmune ... deficiencies • Autoimmune ... and CNS • Headache
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
- Differential ... Diagnosis Framework ... Aldolase levels • EMG ... Other Diseases: • PBC ... #differential #
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