11 results
CNS Ring-Enhancing Lesions - Differential Diagnosis Framework

Ring Completeness
 • Incomplete: Demyelinating Disease
 • Complete (MAGIC):
CNS Ring-Enhancing ... Lesions - Differential ... Metastasis - Autoimmune ... Glioblastoma - Infection ... Diagnosis #neurology
CNS Ring-Enhancing Lesions - Immunocompromised vs Immunocompetent
Multiple Ring-Enhancing Lesions:
 • Toxoplasmosis (CD4 < 100)
 • Other
PCR 50% sensitive ... splenomegaly Other infections ... Infectious: ... #Brain #differential ... causes #radiology #neurology
CNS Infection in HIV / AIDS - Differential Diagnosis Framework

Principles of HIV-Associated CNS Opportunistic Infections:
 •
CNS Infection in ... HIV / AIDS - Differential ... parietal - Size lesions ... #Infections #differential ... InfectiousDiseases #Neurology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... HELLP - Grafts, Valves ... Membrane): - Autoimmune ... Drug-associated, PCH ... Internal (RBC) - Infections
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
Weakness - Differential ... pulmonary etc) • CNS ... necrotizing myopathy • Autoimmune ... electromyographic (EMG ... #Diagnosis #neurology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Intravascular Hemolysis - Differential ... Cold AIHA • Alloimmune ... circulation - Infections ... Cold AIHA • PCH ... Prosthetic heart valves
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Agglutinin Syndrome (CAS ... , autoimmune disorder ... CLL (older) • Autoimmune ... younger pts) Differential ... hemolytic #anemia #hematology
BEE Syndromes - Non-inflammatory Causes

Immune-mediated conditions affecting the Brain, Eye, and Ear

Visual or auditory symptoms in
nervous system (CNS ... an underlying autoimmune ... LHON) plus MRI lesions ... BEE #Syndromes #neurology ... noninflammatory #differential
Myasthenia Gravis Overview

Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction.  Ab to
Myasthenia Gravis is an autoimmune ... Hodgkin lymphoma - Autoimmune ... life-threatening Differential ... Serologic and EMG ... precipitated by: Drugs, infection
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
papulosquamous lesions ... permanent alopecia Differential ... rheumatologic diseases ... fibromyalgia) • Infections ... and CNS • Headache