9 results
Myasthenia Gravis Overview

Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction.  Ab to
Gravis is an autoimmune ... Ab to AChR blocks ... life-threatening Differential ... Diagnosis - ... Serologic and EMG
Causes of Neuromuscular Weakness
 • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Weakness • Spinal ... Poliomyelitis, Guillain-Barre ... Eaton Syndrome, Myasthenia ... #Causes #differential ... #diagnosis #neurology
Generalized Weakness - Differential Diagnosis Framework
"l feel weak":
 • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis
 •
- Differential ... Resp/Heme: CHF, valves ... NMJ disorder (Myasthenia ... Diagnosis #causes ... #neurology
Acid Base Disorders - Blood Gas Interpretation

Steps for Blood Gas Interpretation: 
1. Acidemia or Alkalemia? 
2.
Values • pH: ... Diagnosis: Causes ... Neuromuscular weakness ... (GBS, Myasthenia ... #Summary #Nephrology
Myasthenia Gravis - Summary
 • an autoimmune disease of the postsynaptic neuromuscular junction associated with antibodies
Summary • an autoimmune ... 50 years in men Diagnosis ... More likely to cause ... glucocorticoids - can cause ... #management #neurology
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
Weakness - Differential ... Diagnosis Framework ... Postsynaptic: Myasthenia ... necrotizing myopathy • Autoimmune ... Diagnosis #neurology
Guillain-Barré Syndrome (GBS)
Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness
Epidemiology:
 • Incidence: 1
Guillain-Barré Syndrome ... (GBS) Acute autoimmune ... Incidence: 1 to 2 cases ... SinaiBmoreIMRes #GBS #Guillain ... #management #neurology
Cauda Equina Syndrome Overview

Cauda Equina Syndrome:
 • Prevalence: 1:33,000-100,000 ppl/yr
 • Incidence: 1.5-3.4 million ppl/yr
 •
lumbar spine • MCC ... Tethered cord • Guillain-Barre ... lower extremity weakness ... #diagnosis #causes ... #neurology
Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
- Differential ... Aldolase levels • EMG ... Anti-Synthetase Ab ... statins - probably caused ... #rheumatology #differential