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hepatology algorithm lfts transaminitis acute alkaline arterial biliary causes chemistry cholangitis cirrhosis dehydrogenase elevated elevation embolism enzymes hematology hepatitis hepatocellular
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Injury ... for hepatic pathology ... Liver Injury? ... • R value = (ALT ... #differential #
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential ... Diagnosis Algorithm ... Injury: • Hepatic ... #differential #
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs R-value ... • Liver injury ... replaced by non-hepatic ... #chemistry #diagnosis ... #differential #
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Injury - Differential ... Diagnosis Hepatocellular ... Vasculature • Hepatic ... #Injury #Differential ... #Diagnosis #Causes
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
) Elevation - Differential ... Diagnosis Algorithm ... disturbance (obstructed liver ... Highest • Bone • Liver ... elevation DDX of Hepatic
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
→ Cirrhosis/Liver ... obstruction • ALP ... or higher • Liver ... bile ducts Differential ... malignancies, Hepatic
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Diagnosis Framework ... Syndrome, Ischemic Liver ... considered in all ... Hyperhomocysteinemia - Heparin-induced ... Vasculitis • Injury
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Dehydrogenase (LDH) - Differential ... Diagnosis Framework ... RBCs, muscle, liver ... - Prosthetic valves ... lung injuries Hepatic
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