18 results
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
cells can infiltrate ... • Neutropenia, anemia ... microglobulin Treatment ... Leukemia #diagnosis #workup ... #oncology #hematology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
HELLP - Grafts, Valves ... Drug-associated, PCH ... Defects: Sickle cell ... anemia, Thalassemias ... #Diagnosis #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
• Sickle cell ... Cold AIHA • PCH ... immune-complex hemolytic anemia ... Prosthetic heart valves ... Algorithm #Causes #Hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
• Symptoms of anemia ... • hemolytic anemia ... younger pts) Differential ... disease #hemolytic #anemia ... #hematology #diagnosis
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... factor (GCSF) treatments ... Workup: • Complete ... blood count with differential ... Syndromes #diagnosis #hematology
Giant cell arteritis (GCA)

Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
Giant cell arteritis ... (GCA) Giant cell ... very remarkable w/differential ... systemic complaints- anemia ... Treatment of GCA
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
activity - A low value ... If the value is ... WBC count and differential ... ThromboticThrombocytopenicPurpura #Diagnosis #Workup ... #Hematology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
aseptic meningitis), MCC ... prick test that can ... Behcet disease) Differential ... , AS Treatment: ... signs #symptoms #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Malignancy (e.g. hematologic ... Angioimmunoblastic T-cell ... lymphopenia, low PLT • Anemia ... : • Chronic B-cell
Polycythemia - Differential Diagnosis Algorithm
Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Polycythemia - Differential ... that a one-off value ... Better call hematology ... you’ll do a good workup ... #hematology