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hematology agglutinin algorithm cap causes cold community dehydrogenase disease elevated extravascular globulin hemolytic intravascular laboratory ldh management monoclonal oncology paraproteinemias
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... HELLP - Grafts, Valves ... Membrane): - Autoimmune ... Defects: Sickle cell anemia ... Haptoglobin ↓ - Lactate
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential ... Diagnosis Algorithm ... Cold AIHA • PCH ... anemia • ... Prosthetic heart valves
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Elevated Lactate ... Dehydrogenase (LDH) - Differential ... Diagnosis Framework ... cell enzymes - Acquired ... - Prosthetic valves
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
activity - A low value ... If the value is ... elevation Serum lactate ... WBC count and differential ... #Workup #Hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Viral infection, autoimmune ... Diagnosis: • hemolytic ... Hyperbilirubinemia • Elevated lactate ... CLL (older) • Autoimmune ... younger pts) Differential
Community Acquired Pneumonia (CAP) - Diagnosis and Management Pneumonia Signs/Symptoms: • Confusion/disorientation (LR + 1.9) • Cough
- Diagnosis and ... Bands > 15% • Uremia ... negative predictive value ... cultures/nasal PCR ... #Diagnosis #Management
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
angioedema • vWD • acquired ... • Coombs (-) hemolytic ... anemia due to cold ... Pseudohyponatremia • ↓anion gap ... #Diagnosis #Oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... Cirrhosis, ETOH, autoimmune ... Thalassemia, Sickle cell anemia ... #ProteinGap #differential ... #diagnosis #hematology
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