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hematology causes extravascular hemolytic intravascular agglutinin algorithm classification cold dehydrogenase disease elevated gap hodgkins laboratory ldh management oncology protein proteingap
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... anemia): ... e.g. lupus, CLL, lymphoma ... - Drugs (Beta lactam ... Extravascular #Causes #differential
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... HELLP - Grafts, Valves ... Membrane): - Autoimmune ... Defects: Sickle cell anemia ... Haptoglobin ↓ - Lactate
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential ... Diagnosis Algorithm ... Cold AIHA • PCH ... anemia • ... Prosthetic heart valves
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
disorder or lymphoid ... - Monoclonal - Lymphoid ... Diagnosis: • hemolytic ... Hyperbilirubinemia • Elevated lactate ... younger pts) Differential
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Elevated Lactate ... Dehydrogenase (LDH) - Differential ... Diagnosis Framework ... - Prosthetic valves ... Malignancy: • Lymphomas
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
activity - A low value ... If the value is ... elevation Serum lactate ... WBC count and differential ... #Workup #Hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Immunosuppression • Autoimmune ... nodosum • Immune hemolytic ... anemia • Pain ... Workup: • Full ... Immunohistochemical studies (to differentiate
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... Cirrhosis, ETOH, autoimmune ... Thalassemia, Sickle cell anemia ... Gap #ProteinGap #differential ... #diagnosis #hematology
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