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hematology agglutinin causes classification cold dehydrogenase disease elevated elevation hemolytic hyperkalemia k laboratory lactic management nephrology oncology plasmacytoma potassium solitary
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Elevated Lactate ... ) - Differential ... Diagnosis Framework ... - Prosthetic valves ... #diagnosis #Laboratory
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... HELLP - Grafts, Valves ... Defects: Sickle cell ... anemia, Thalassemias ... Haptoglobin ↓ - Lactate
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
If the value is ... elevation Serum lactate ... dehydrogenase (LDH ... WBC count and differential ... #Workup #Hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Diagnosis: • hemolytic ... anemia • Cold ... Hyperbilirubinemia • Elevated lactate ... younger pts) Differential ... Disorders Such As
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
- Differential ... e.g., uptake by cells ... to bolus these values ... 30mmHg) - Severe anemia ... #Elevation #Differential
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
, Cell Lysis (TLS ... injury, ischemia, hemolysis ... reabsorption) Workup ... ), CK+LDH (lysis ... Drives K+ into cells
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
• No CRAB - no anemia ... lytic lesions • Lactate ... dehydrogenase (LDH ... diff • CMP, Ca, LDH ... #Workup #Hematology
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