21 results
Blood Disorders - Markers and Differential Diagnosis Algorithm 
Acute
 • Myloid (AML) - CD13, CD33, CD34,
Blood Disorders ... Diagnosis Algorithm ... - CD7, CD3 Chronic ... Pelger-Huet, Macrocytic anemia ... Myelofibrosis (MF
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
HELLP - Grafts, Valves ... Defects: Sickle cell ... anemia, Thalassemias ... Haptoglobin ↓ - Lactate ... - Peripheral Blood
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... cell count (anemia ... Marrow Failure • Chronic ... differential • ... Myelodysplastic #Syndromes #diagnosis
Some of the techniques used for Antenatal Diagnosis

Amniocentesis 
 - Chromosome/micro-array and DNA analysis 
 -
Fetal blood sampling ... haemoglobin for anaemia ... transfusion Chorionic ... villus sampling ... genetic analysis of cells
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Hyperbilirubinemia • Elevated lactate ... younger pts) Differential ... Disorders Such As ... sensitize red blood ... cells (RBCs) at
Causes of Wide Pulse Pressure - Differential Diagnosis
Physiologic:
 • Advanced age-arteriosclerosis (less compliant arteries)
 • Well
Diagnosis Physiologic ... compliant arteries) • Well ... (reduced blood ... disorders - Chronic ... fistula - Such as
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework

LDH is a cytoplasmic enzyme present in tissues throughout
Elevated Lactate ... Dehydrogenase (LDH) - Differential ... Diagnosis Framework ... deficiency of red blood ... - Prosthetic valves
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis

The most common causes of hyperlactatemia are usually:
Lactic Acidosis - Differential ... removal from the blood ... e.g., uptake by cells ... to bolus these values ... 30mmHg) - Severe anemia
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
If the value is ... of Peripheral blood ... elevation Serum lactate ... WBC count and differential ... #Workup #Hematology
Acid Base Disorders - Blood Gas Interpretation

Steps for Blood Gas Interpretation: 
1. Acidemia or Alkalemia? 
2.
Base Disorders - Blood ... Interpretation Steps for Blood ... And BMP Normal Values ... Diagnosis: Causes ... Renal failure (uremia