EMF pcc differential valgus workup diagnosis anemia im hematology disorders cold abg - GrepMed

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Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
-

Diagnosis Algorithm ... AIHA • PCH ... immune-complex hemolytic anemia ... Prosthetic heart valves ... #Causes #Hematology

Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
1. Cold Agglutinins (CAD)
2. Donath-Landsteiner

lymphoproliferative disorder ... • Symptoms of anemia ... anemia • Cold ... younger pts) Differential ... #hematology #diagnosis

Hemolysis - Differential Diagnosis Framework

1) Environment
- Fragmentation
- MAHA: TTP, HUS, DIC, HELLP

HELLP - Grafts, Valves ... Autoimmune: Warm AIHA, Cold ... Drug-associated, PCH ... Defects: Sickle cell anemia ... #Diagnosis #hematology

Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
- Prior platelet count, family

- Differential ... Diagnosis and Workup ... practices that could ... changes), high MCV anemia ... #Workup #hematology

Hemolytic Anemia - Differential Diagnosis Algorithm
• Sickle cells - Consider sickle cell disease (diverse genotypes):

Hemolytic Anemia ... - Differential ... Agglutination - Cold ... Consider RBC membrane disorder ... #workup #hematology

Acid Base Disorders - Blood Gas Interpretation

Steps for Blood Gas Interpretation:
1. Acidemia or Alkalemia?
2.

Acid Base Disorders ... Values • pH: ... Diagnosis: Causes ... Renal failure (uremia ... lung disease (COPD

Stiff Person Syndrome (SPS) - Diagnosis and Management Summary

Epidemiology:
• Prevalence: 1-2 cases per million -

and pernicious anemia ... brain and spinal cord ... : • Anti-GAD Ab ... antibody that works ... limb or joint disorders

SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and

permanent alopecia Differential ... Diagnosis: • ANCA-associated ... vein thrombosis Hematologic ... lymphopenia, low PLT • Anemia ... Erythematosus #Diagnosis

Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly

are a group of disorders ... formed or don’t work ... blood count with differential ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology

Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•

Albumin > 4) Work-up ... Connective tissue disorders ... Thalassemia, Sickle cell anemia ... Gap #ProteinGap #differential ... #diagnosis #hematology

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