21 results
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Diagnosis Framework ... HELLP - Grafts, Valves ... Membrane): - Autoimmune ... Drug-associated, PCH ... Hypophostphatemia Laboratory
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
common in SLE, autoimmune ... microsomal) - Autoimmune ... biliary cirrhosis (PBC ... Endomyseal antibody (EMA ... #diagnosis #table
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
normal or slightly elevated ... Normal early on but elevated ... Diagnosis: • ... bile ducts Differential ... #workup #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... - Differential ... • Ischemia • Autoimmune ... • Cholestatic disease ... Bile Ducts • PSC
Non-ACS Myocardial Injury - Elevated Troponin Differential Diagnosis and Workup Algorithm

 • Chronic Myocardial Injury: End
Myocardial Injury - Elevated ... Troponin Differential ... Diagnosis and Workup ... End Stage Renal Disease ... Occlusion • Stable
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory ... hallmark for the disease ... If the value is ... WBC count and differential ... #Workup #Hematology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Liver Injury - Differential ... Diagnosis Algorithm ... • Autoimmune: ... Autoimmune hepatitis ... specificity to elevated
Commonly Used Diagnostic Tests for Celiac Disease

Tissue transglutaminase (tTG) IgA antibodies
 - Most reliable noninvasive test
Commonly Used Diagnostic ... negative predictive value ... #Testing #Laboratory ... #Tests #Diagnosis ... #Workup #Table
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
Autoimmune Hepatitis ... from subclinical disease ... reported (eg AIH-PBC ... IgG typically elevated ... Necrosis) If mild laboratory
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework

LDH is a cytoplasmic enzyme present in tissues throughout
Dehydrogenase (LDH) - Differential ... Diagnosis Framework ... - Prosthetic valves ... #differential # ... diagnosis #Laboratory