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diagnosis differential causes management rheumatology workup algorithm secondary systemic classification dermatology erythematosus lupus neurology sle treatment acidosis activation arthritis b12
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
(usually IgG) (e.g ... (usually IgM) (e.g ... lymphoproliferative disorders ... deficiencies (e.g ... differential #diagnosis #hematology
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Nail Disorders secondary ... Iron deficiency anemia ... halt nail growth (e.g ... Discoloration • Medications ... • Nephrotic syndrome
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
malignancies • Anemia ... Chronic inflammatory disorders ... (e.g. autoimmune ... Myelodysplastic syndrome ... Diagnosis #Causes #hematology
Consensus Indications for Irradiated RBC Transfusions: Cellular blood components are irradiated for the prevention of TA-GVHD. Transfused
Consensus Indications ... immunodeficiency disorders ... (DiGeorge Syndrome ... HLA-selected products (e.g ... #Hematology #BloodBank
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Increased Requirement (e.g ... • Small Bowel Disorder ... Myelodysplastic Syndromes ... Algorithm #Causes #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
family history - Medications ... function test, ANA (e.g ... changes), high MCV anemia ... or if a primary hematologic ... Causes #Workup #hematology
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Neoplastic / Hematologic ... • Anemia • ... • Drug Abuse (e.g ... • Somatization Disorder ... Chronic Fatigue Syndrome
Indications for Serum Protein Electrophoresis (SPEP) • Suspected multiple myeloma, Waldenström's macroglobulinemia, primary amyloidosis, or related
Indications for ... amyloidosis, or related disorder ... • New-onset anemia ... possible malignancy (e.g ... Electrophoresis #SPEP #Hematology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
: • Clinical triad ... hematological disorders ... to Autoimmune Disorders ... (e.g. systemic ... classification #rheumatology
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
dietary intake (e.g ... dysfunction, and/or disorders ... intrinsic factor, IF) Clinical ... organ ischemia (e.g ... other diagnosis e.g
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