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diagnosis causes differential algorithm management rheumatology systemic erythematosus lupus neurology pediatrics secondary sle treatment bleeding bruising cerebritis chronic cns crisis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
(usually IgG) (e.g ... (usually IgM) (e.g ... lymphoproliferative disorders ... deficiencies (e.g ... differential #diagnosis #hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
malignancies • Anemia ... Chronic inflammatory disorders ... (e.g. autoimmune ... Myelodysplastic syndrome ... Diagnosis #Causes #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Increased Requirement (e.g ... • Small Bowel Disorder ... Myelodysplastic Syndromes ... Algorithm #Causes #Hematology
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Nail Disorders secondary ... Iron deficiency anemia ... halt nail growth (e.g ... • Nephrotic syndrome ... Systemic #Secondary #dermatology
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Neoplastic / Hematologic ... • Anemia • ... • Drug Abuse (e.g ... • Somatization Disorder ... Chronic Fatigue Syndrome
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... Headache, Movement disorders ... , Seizure disorders ... Disease, PRES Pathophysiology ... Lumbar Puncture, EEG
Stiff Person Syndrome (SPS) - Diagnosis and Management Summary Epidemiology: • Prevalence: 1-2 cases per million -
and pernicious anemia ... Pathophysiology ... unit activity on EMG ... of diazepam • EMG ... TPO, TTG, etc EMG
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
infiltration (e.g ... , e.g. ... bypass Vascular disorders ... - Vasculitis, e.g ... Bruising #Causes #peds
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
• Malignancy (e.g ... . hematologic) ... (e.g. thyroid disease ... vein thrombosis Hematologic ... lymphopenia, low PLT • Anemia
Scleroderma Renal Crisis (SRC) Clinical Presentation of Scleroderma Renal Crisis: 1) Acute kidney injury 2) Abrupt onset of hypertension 3)
microangiopathic hemolytic anemia ... (MAHA) Pathophysiology ... other pathology (e.g ... (short-acting, e.g ... vasodilators (ERAs
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