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rheumatology hepatitis management autoimmune erythematosus sle systemic activation ah alcoholic anemia bleeding causes cerebritis classification cns criteria cryoglobulinemia cryoglobulins differential
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
(usually IgG) (e.g ... . lupus, CLL, lymphoma ... (usually IgM) (e.g ... deficiencies (e.g ... #hematology #anemia
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE) Clinical ... Demyelinating Syndrome ... permeability Diagnosis ... Lumbar Puncture, EEG ... #cerebritis #diagnosis
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
inflammation (eg ... been reported (eg ... , AIH diagnosis ... of Hepatitis (eg ... #Hepatology
Clinical Diagnosis of Autoimmune Hepatitis - Onset of jaundice within prior 8 weeks - Ongoing consumption
Clinical Diagnosis ... ischemic hepatitis (e.g ... use assessment (e.g ... laboratory tests (e.g ... #Hepatology #AIH
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
underlying disease (eg ... SJIA], systemic lupus ... • Infection (eg ... #Diagnosis #Management ... #Hematology #Rheumatology
Clinical diagnosis of Alcoholic Hepatitis (AH) • Onset of jaundice within prior 8 weeks • Ongoing
Clinical diagnosis ... ischemic hepatitis (e.g ... use assessment (e.g ... laboratory tests (e.g ... #hepatology #criteria
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... • Malignancy (e.g ... . hematologic) ... Endocrine disorders (e.g ... : • AIHA 10% •
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
: • Clinical triad ... Labs/Diagnosis: ... tissue disorder (e.g ... . systemic lupus ... Cryoglobulins #diagnosis
Helpful Clinical Features in Evaluating Bleeding Disorders Age of onset • Neonate - in 20% of haemophilias,
Helpful Clinical ... Drug history, e.g ... connective tissue, e.g ... Marfan syndrome, ... #hematology #primarycare
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