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diagnosis rheumatology management systemic activation bruising causes cerebritis classification cryoglobulinemia cryoglobulins differential disease laboratory macrophage mas neurology peds purpura rheumatic
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... • Malignancy (e.g ... . hematologic) ... Endocrine disorders (e.g ... and CNS • Headache
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... Erythematosus ( ... Demyelinating Syndrome ... Lumbar Puncture, EEG ... #SLE #CNS #neurology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
nervous system (CNS ... underlying disease (eg ... SLE], AOSD) • Infection ... (eg, visceral leishmaniasis ... Diagnosis #Management #Hematology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
diseases: - 10% SLE ... tissue disorder (e.g ... . systemic lupus ... erythematosus ( ... SLE), rheumatoid
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
(systemic lupus ... erythematosus) ... infiltration (e.g ... Rare disorders, e.g ... - Vasculitis, e.g
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... joint • Systemic lupus ... erythematosus ( ... inflammatory disease (e.g ... Chemistry profile (e.g
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