5 results
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
Guillain-Barré syndrome ... GBS), systemic lupus ... antisynthetase syndrome ... (SAMS-CI) • EMG ... myopathy #diagnosis #management
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... Lumbar Puncture, EEG ... Secondary prevention (statin ... CNS #neurology #rheumatology ... cerebritis #diagnosis #management
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
manifestations: from easy bruising ... underlying disease (eg ... • Infection (eg ... #Diagnosis #Management ... #Hematology #Rheumatology
Causes of Purpura or Easy Bruising in Children

Platelet count reduced, i.e. thrombocytopenia
 - Increased platelet destruction
SLE (systemic lupus ... infiltration (e.g ... Rare disorders, e.g ... - Vasculitis, e.g ... #Causes #peds #pediatrics
Helpful Clinical Features in Evaluating Bleeding Disorders
Age of onset
 • Neonate - in 20% of haemophilias,
may present when starting ... Drug history, e.g ... connective tissue, e.g ... Marfan syndrome, ... #diagnosis #hematology