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differential causes rheumatology management abscess activation bleeding bruising crisis disorders erythematosus extravascular hemolysis hemolytic hepatology history intravascular liver macrophage mas
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
(usually IgG) (e.g ... . lupus, CLL, lymphoma ... (usually IgM) (e.g ... deficiencies (e.g ... #hematology #anemia
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Easy Bruising in Children ... infiltration (e.g ... Rare disorders, e.g ... - Vasculitis, e.g ... #pediatrics #diagnosis
Causes of Acute Pericarditis: Infectious; Viral: Adenovirus Coxsackie virus A and B Echovirus Epstein-Barr virus Hepatitis Human immunodeficiency
pneurnoniae (in children ... Cardiac injury (e.g ... Pericardial perforation (e.g ... Systemic lupus ... #Differential #Diagnosis
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 Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
underlying disease (eg ... • Infection (eg ... with leukopenia, anemia ... #Diagnosis #Management ... #Hematology #Rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... • Malignancy (e.g ... . hematologic) ... Endocrine disorders (e.g ... lymphopenia, low PLT • Anemia
Pyogenic liver abscess in children Common bacterial causes in children: • S.aureus • Strep spp • Enteric
Hepatic artery (e.g ... liver #abscess #pediatrics ... #children #peds ... #differential #diagnosis ... #hepatology
Scleroderma Renal Crisis (SRC) Clinical Presentation of Scleroderma Renal Crisis: 1) Acute kidney injury 2) Abrupt onset of hypertension 3)
microangiopathic hemolytic anemia ... other pathology (e.g ... (short-acting, e.g ... , add other BP meds ... vasodilators (ERAs
Helpful Clinical Features in Evaluating Bleeding Disorders Age of onset • Neonate - in 20% of haemophilias,
Drug history, e.g ... connective tissue, e.g ... Marfan syndrome, ... Disorders #History #peds ... #pediatrics #diagnosis
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