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diagnosis differential causes rheumatology abscess activation anemia bleeding bruising classification cryoglobulinemia cryoglobulins disorders extravascular hemolysis hemolytic hepatology history intravascular liver
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Easy Bruising in Children ... SLE (systemic lupus ... infiltration (e.g ... Rare disorders, e.g ... - Vasculitis, e.g
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
thrombocytopenic purpura ... (usually IgG) (e.g ... . lupus, CLL, lymphoma ... (usually IgM) (e.g ... deficiencies (e.g
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
disease • Systemic lupus ... (Petechial or purpuric ... underlying disease (eg ... SJIA], systemic lupus ... • Infection (eg
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Arthralgia - Purpura ... triad of Palpable purpura ... tissue disorder (e.g ... . systemic lupus ... classification #rheumatology
Pyogenic liver abscess in children Common bacterial causes in children: • S.aureus • Strep spp • Enteric
liver abscess in children ... Hepatic artery (e.g ... liver #abscess #pediatrics ... #children #peds ... differential #diagnosis #hepatology
Helpful Clinical Features in Evaluating Bleeding Disorders Age of onset • Neonate - in 20% of haemophilias,
Drug history, e.g ... connective tissue, e.g ... Marfan syndrome, ... Disorders #History #peds ... #pediatrics #diagnosis
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