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diagnosis management differential algorithm causes rheumatology secondary thrombocytosis acquired activation apml cell cll differentiation disorders eosinophil eosinophilia essential et hemophilia
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... for workup, including ... Rebound effect from treatment ... • Infections: Chronic ... Diagnosis #Algorithm #hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
hemorrhage) • Chronic ... inflammatory disorders (e.g ... Myelodysplastic syndrome ... Myelofibrosis (MF) • Chronic ... Diagnosis #Causes #hematology
Acquired von Willebrand Syndrome - Diagnosis and Management • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
von Willebrand Syndrome ... Lymphoproliferative disorders (e.g ... Myeloproliferative disorders (e.g ... Diagnosis #Management #treatment ... #hematology #differential
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
evaluation or workup ... 1,500 cells/µL Workup ... glucocorticoid treatment ... signs or symptoms (eg ... Differential #diagnosis #hematology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
organ damage • Treatment ... Low calcium • Treatment ... - Hyperkalemia treatment ... unless worrisome EKG ... diagnosis #management #hematology
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
halt nail growth (e.g ... discoloration) • Chronic ... • Nephrotic syndrome ... Systemic #Secondary #dermatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... microglobulin Treatment ... • Richter’s Syndrome ... Leukemia #diagnosis #workup ... #oncology #hematology
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
hemophilia type (e.g ... Classify severity Treatment ... Chronic Management ... by a hemophilia treatment ... #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Prednisone 5mg/kg ... diagnosis #management #hematology ... #oncology
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
a rare chronic ... and lower jaw Treatment ... antiinflammatory properties e.g ... #Rheumatology # ... diagnosis #management #Dermatology
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