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diagnosis rheumatology differential management erythematosus joint lupus systemic activation algorithm approach autoimmune behcet causes cerebritis chronic classification cns conditions cryoglobulinemia
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Associated with Joint Pain ... Vasculitis (e.g. ... , PAN) • Seizures ... conditions #joint #pain ... differential #diagnosis #rheumatology
Approach to Joint Pain History: Is the pain from: • Joint • Adjacent bursa • Tendon • Ligament • Bone • Muscle • Referred from
joint trauma (e.g ... joint alterations (e.g ... subchondral bone (e.g ... derangements (e.g ... #approach #workup
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Oral aphthae : SLE ... : SLE, Reactive ... Arthritis, AS Treatment ... Nonsurgical abdominal pain ... signs #symptoms #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
(eg, systemic juvenile ... erythematosus [SLE ... • Infection (eg ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
• Malignancy (e.g ... . hematologic) ... Endocrine disorders (e.g ... Joint pain • Swan ... vein thrombosis Hematologic
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Neoplastic / Hematologic ... • Rheumatoid Arthritis ... • SLE • Polymyalgia ... • Drug Abuse (e.g ... Chronic Fatigue Syndrome
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... (e.g., polymyalgia ... Chemistry profile (e.g ... , and low back pain ... #laboratory #workup
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... Demyelinating Syndrome ... Cerebrovascular Disease ... Lumbar Puncture, EEG ... Treatment:
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Autoimmune diseases ... : - 10% SLE or ... tissue disorder (e.g ... erythematosus (SLE ... ), rheumatoid arthritis
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
nonerosive inflammatory arthritis ... thickening • Osteitis: pain ... and lower jaw Treatment ... antiinflammatory properties e.g ... osteoarticular and skin disease
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