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hematology hemophagocytic hlh lymphohistiocytosis oncology rheumatology activation algorithm anemia aplastic apml calcium cppd deposition dermatologic differentiation disease dress eim esophageal
Dermatologic Extraintestinal Manifestations in IBD - IBD Algorithm Erythema Nodosum Pyoderma Gangrenosum Metastatic Crohn's Disease Sweet Syndrome EBA Dr. Wade Billings @wabillin #Dermatologic
Disease Sweet Syndrome ... Manifestations #EIM ... IBD #Algorithm #gastroenterology ... #management #dermatology ... #diagnosis
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
- 80% have fever ... organ damage • Treatment ... Low calcium • Treatment ... #TLS #diagnosis ... #management #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Subacute-Acute: • Common: fever ... Renal Failure Treatment ... #management #hematology
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Definition: • Severe adverse drug reaction, characterized by
Fever >38.5 2. ... disease: symptomatic treatment ... SinaiBmoreIMRes #DRESS #Syndrome ... #dermatology #diagnosis ... #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
disease • Periodic fever ... - Nonremitting fever ... Treatment: • Corticosteroids ... #Diagnosis #Management ... #Hematology #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... following: • Fever ... • Bicytopenia Treatment ... #management #treatment ... #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Presentation: • Fever ... recurrent infections/fevers ... aplastic anemia Treatment ... Anemia #oncology #hematology ... #diagnosis #management
Esophageal Necrosis Etiology: - Ischemia and Gastric Outlet Obstruction with GERD may be inciting events - Associated
Stevens-Johnson syndrome ... third of esophagus Treatment ... : - Treatment of ... most common long term ... #management #gastroenterology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... hyperinflammatory syndrome ... Fever b. ... Treatment Approach ... #Management #Hematology
Pseudogout Summary - Calcium Pyrophosphate Deposition Disease (CPPD) Pathophysiology: Pyrophosphate produced by chondrocytes likely precipitates with calcium to
Acute Pseudogout: Treatment ... attacks • Long-term ... Crowned Dens Syndrome ... acute neck pain, fever ... #management
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