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management differential symptoms dermatology syndrome arthritis classification dermatomyositis disease infections infectiousdiseases ra systemic vasculitis aids antimda5 antimda5dm antinxp2 antinxp2dm apml
Causes of Bone/Joint Pain in Sickle Cell Disease Vaso-occlusive pain: • Mechanism: ischemic pain • Can present
Causes of Bone/Joint ... Generally affects long ... #Joint #Pain #SickleCell ... #differential #diagnosis ... #causes #hematology
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
lesions + Rheumatic pain ... thickening • Osteitis: pain ... • Bone and joint ... Rule out other causes ... SAPHO #Syndrome #Rheumatology
Pott's Disease in Tuberculosis - Diagnosis and Management Summary Epidemiology: - Typically from TB endemic areas -
extrapulmonary cases ... Clinical Signs ... of bacilli to bone ... /joints via hematogenous ... tissue damage - CXR
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
effusion, Restrictive lung ... lesions Abdominal pain ... erythematosus #signs ... #symptoms #diagnosis ... #rheumatology
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
Renal disease - Cr ... g/dl LLN B - Bony ... Causes of false- ... Gammopathies #MGUS #diagnosis ... #hematology #oncology
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
skin thickening Signs ... (interstitial lung ... Musculoskeletal: joint ... Scleroderma #SSc #rheumatology ... #diagnosis #signs
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
Differential Diagnosis ... noninflammatory Signs ... weeks) Can Be Caused ... #Diagnosis #MSK ... #rheumatology #
Rheumatoid arthritis (RA): Extra-articular manifestations Skin: • Inflammation of skin (esp. over areas of stress) forms
pleural effusion on CXR ... inflammation tends to cause ... disease/pulmonary ... pathophysiology #signs ... #symptoms #diagnosis
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Pain Eyes ... Wilson's disease Pulmonary ... • Interstitial lung ... • Shrinking lung ... #diagnosis #rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... pain, fever, joint ... manifestations, hypoxia, CXR ... #Leukemia #Hematology ... #Oncology #Diagnosis
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