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Nephron - Diuretic Sites of Action

Source Text: https://www.sciencedirect.com/book/9780323449427/critical-care-nephrology#book-info

#Nephron #Diuretics #Site #Action #Location #Nephrology #Pathophysiology #Pharmacology
Nephron - Diuretic ... Sites of Action ... #Site #Action # ... Location #Nephrology ... #Pathophysiology
Nephron Pathophysiology - Diuretic Sites of Action
Diuretics
1) Acetazolamide/canagliflozin
2) Osmotic agents (mannitol, urearetics)
3) Loop agents (eg, furosemide)
4)
Nephron Pathophysiology ... - Diuretic Sites ... of Action Diuretics ... Adenosine #Nephron #Pathophysiology ... #Action #nephrology
Mechanism of Action of Diuretics
Amiloride, Triamterene, Spironolactone
Loop Diuretics
Thiazides
Acetazolamide

#Diuretics #Mechanism #Action #pharmacology #pathophysiology #nephrology
Mechanism of Action ... of Diuretics Amiloride ... #Mechanism #Action ... #pharmacology #pathophysiology ... #nephrology
Hormones Acting on the Nephron - Diuretics and Their Site of Action
 1) Acetazolamide
 2) Osmotic
Hormones Acting ... the Nephron - Diuretics ... Their Site of Action ... spironolactone) #Pathophysiology ... #Nephrology #Nephron
Causes of Hypokalemia
Transcellular Shifts:
 - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
Causes of Hypokalemia ... ß-Adrenergic agonists, Hypokalemic ... congenital), Thyrotoxic hypokalemic ... , nasogastric suction ... differential #diagnosis #nephrology
Hypokalemia - Differential Diagnosis Algorithm

Transcellular Shift:
 • Alkalosis
 • ↑ beta-2 adrenergic simulation 
 • Erythropoiesis
Hypokalemia - Differential ... • G-CSF • Hypokalemic ... GI losses (NG suction ... • Discontinued diuretic ... Diagnosis #Algorithm #nephrology
Causes of High-anion Gap and Non-anion Gap Metabolic Acidosis
Causes of High-anion Gap Acidosis:
 • Lactic acidosis
Hypokalemia ... Hyperkalemia ... Drug-induced hyperkalemia ... Potassium-sparing diuretics ... diagnosis #causes #nephrology
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine
Urine K+
patients with hypokalemia ... Non-reabsorbable anion ... Urine Cl - Loop diuretics ... , Thiazide diuretics ... algorithm #diagnosis #nephrology
Hyperkalemia - Diagnosis and Management - GrepMed Handbook

S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
G-K), K-sparing diuretics ... (IV loop diuretic ... Exchanges K+ for cations ... (10g PO tid) - caution ... Treatment #potassium #nephrology
Physiologic Approach to Hypotonic Hyponatremia
The next time you have a case of hypotonic hyponatremia, give the
Renal Sodium loss (diuretics ... (AKI, Post-AKI diuresis ... ) RAAS Active (or ... Present (Uosm ≥100): Hypovolemia ... table #sodium #nephrology