87 results
Switching Between Anticoagulants and DOACs
VKA, Dabigatran, Rivaroxaban, Apixaban, Edoxaban, Betrixaban, DOAC, Parenteral anticoagulant

DOI: 10.1161/JAHA.120.017559

#Anticoagulants #DOACs #anticoagulation
Switching Between Anticoagulants ... Rivaroxaban, Apixaban, Edoxaban ... DOAC, Parenteral anticoagulant ... JAHA.120.017559 #Anticoagulants
Oral anticoagulant dosing and bridging for VTE

- Dr. Joseph Shatzel @Clotmaster 

#VTE #DOAC #Bridging #Dosing #Oral
Oral anticoagulant ... #Dosing #Oral #Anticoagulant ... #Rivaroxaban #Edoxaban
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis.

Currently, edoxaban and rivaroxaban are the only
Currently, edoxaban ... direct-acting oral anticoagulants ... being stronger for edoxaban ... direct-acting oral anticoagulant
Coagulation Cascade - Actions of Anticoagulants
 • Heparin: Unfractionated heparin, Enoxaparin, Daltaparin
 • Fondaparinux
 • Direct
Cascade - Actions of Anticoagulants ... Rivaroxaban, Apixaban, Edoxaban ... Coagulation #Cascade #Anticoagulants
Effect of Anticoagulants on Coagulation Tests
PT / INR, aPTT, Anti-Xa Activity, Activated Clotting Time, Thrombin Time,
Effect of Anticoagulants ... Rivaroxaban Apixaban, Edoxaban ... EricsMedicalLectures/ #Anticoagulants
Choice of anticoagulant for treatment of pulmonary embolism
 • Malignancy - LMWH
 • To avoid parenteral
Choice of anticoagulant ... - Rivaroxaban; edoxaban ... Pregnancy - LMWH #anticoagulant
Pharmacokinetic Characteristics and Primary Routes of Clearance of Oral Anticoagulant Agents

Warfarin - 100% Hepatic, 0% Renal
Apixaban
Clearance of Oral Anticoagulant ... Hepatic, 80% Renal Edoxaban
Anticoagulant Sites of Absorption
Apixaban - Primarily proximal small intestine; some gastric absorption
Dabigatran - Lower stomach and
Anticoagulant Sites ... and duodenum Edoxaban ... - Proximal #Anticoagulant
Anticoagulants Common Reversal Agents
 - Warfarin (Coumadin) → Vitamin K (Phytonadione), 4-factor PCC (Kcentra)
 - Heparin/LMWH
Anticoagulants Common ... Betrixaban (Bevyxxa), Edoxaban
DOAC Reversal
Emergency surgery or urgent procedure
Stop anticoagulant treatment; volume resuscitation and transfusion as needed
Antidotes:
 • Apixaban,
procedure Stop anticoagulant ... : • Apixaban, Edoxaban ... Reversal #NOAC #Oral #anticoagulant