349 results
Oral anticoagulant dosing and bridging for VTE

- Dr. Joseph Shatzel @Clotmaster 

#VTE #DOAC #Bridging #Dosing #Oral
Oral anticoagulant ... Bridging #Dosing #Oral ... #Rivaroxaban #Edoxaban
Pharmacokinetic Characteristics and Primary Routes of Clearance of Oral Anticoagulant Agents

Warfarin - 100% Hepatic, 0% Renal
Apixaban
of Clearance of Oral ... Hepatic, 80% Renal Edoxaban ... Pharmacology #Clearance #oral
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis.

Currently, edoxaban and rivaroxaban are the only
Currently, edoxaban ... direct-acting oral ... being stronger for edoxaban ... direct-acting oral
Edoxaban for the Treatment of Cancer-Associated Venous Thromboembolism

https://www.nejm.org/doi/full/10.1056/NEJMoa1711948

Authors’ Conclusions: “Oral edoxaban was noninferior to subcutaneous dalteparin
Edoxaban for the ... Conclusions: “Oral ... edoxaban was noninferior ... would have been “oral ... edoxaban had a
Choice of anticoagulant for treatment of pulmonary embolism
 • Malignancy - LMWH
 • To avoid parenteral
• Once a day oral ... - Rivaroxaban; edoxaban
Xa Inhibitors - Apixaban and Rivaroxaban 
Oral Xa inhibitors are recommended by CHEST as first-line for
Rivaroxaban Oral ... indications and edoxaban
DOAC Reversal
Emergency surgery or urgent procedure
Stop anticoagulant treatment; volume resuscitation and transfusion as needed
Antidotes:
 • Apixaban,
: • Apixaban, Edoxaban ... Reversal #NOAC #Oral
Treatment algorithm for VTE in Malignancy

(A) Suggested treatment algorithm for symptomatic and incidental DVT or PE
**Edoxaban is initiated ... DOAC, direct oral
Effect of Direct Oral Anticoagulants on Hemostatic Tests
Horizontal bars correspond to the approximate range of detectability
Effect of Direct Oral ... , apixaban and edoxaban
Perioperative Management of DOACs
Problem:
 ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
direct acting oral ... ) • Apixaban, Edoxaban