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diagnosis management rheumatology hemophagocytic hlh lupus lymphohistiocytosis sle systemic antinxp2 antinxp2dm behcet brain cerebritis chronic cll cns crypto cryptococcal dermatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Systemic Lupus Erythematosus ... (SLE) Clinical ... disorders, Aseptic Meningitis ... #SLE #CNS #neurology ... #rheumatology #
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... lymphoproliferative syndrome Clinical ... (hypertension, lower ... sediment, and elevated ... PAC • Aseptic meningitis
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... Diagnosis: HLH signs ... >500 ng/mL • Elevated ... • Bicytopenia Treatment ... #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... Physical Exam/Signs ... Elevated LDH 5. ... microglobulin Treatment ... workup #oncology #hematology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
association • M > F Clinical ... skin injury) • Neurologic ... lesions, aseptic meningitis ... Arthritis, AS Treatment ... diagnosis #management #signs
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
purpura: Strong sign ... affects the skin, neurologic ... ischemia • Skin: Erythematous ... cognitive impairment, neurologic ... Mono Multiplex, Elevated
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
with edema • Erythematous ... chest (in a V-sign ... shoulders (in a shawl sign ... auricular papules Clinical ... positive patients Treatment
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
Clinical Presentation ... • Common Signs ... Hyperferritinemia - Elevated ... Elevated soluble ... Diagnosis #Management #Hematology
Cryptococcal meningitis on T2 MRI 30 M from sub-Saharan Africa presents w/ progressive Headache x1 mo, +neck
organism (soap bubble sign ... level is sometimes elevated ... Standard treatment ... prophylaxis with a lower ... T2 #MRI #Brain #clinical
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