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diagnosis hlh lymphohistiocytosis activation apml differential differentiation hemeonc macrophage mas monoclonal paraproteinemias rheumatology treatment
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Hemophagocytic Lymphohistiocytosis ... Overwhelming clinical syndrome ... lymph node, or liver ... Lymphohistiocytosis #diagnosis #management ... #treatment #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation Syndrome ... A subset of hemophagocytic ... thrombocytopenia • Liver ... #Diagnosis #Management ... #Hematology #Rheumatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... if WBC > 5 or elevated ... Differentiation #Syndrome ... APML #diagnosis #management ... #hematology #oncology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
capillary leak syndrome ... • Erythema elevatum ... Thrombosis in vascular beds-renal ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
Hemophagocytic Lymphohistiocytosis ... liver enzymes ... Elevated soluble ... #HLH #Hemophagocytic ... #Hematology #HemeOnc
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