11 results
Adult-Onset Still's Disease (AOSD)
Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
likely conditions (autoimmune ... Elevated IL-18, ... BrighamChiefs #AdultOnset ... Disease #AOSD #rheumatology ... #diagnosis #management
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
Warm Antibody Autoimmune ... • Blood smear: Differential ... 2) LOOK FOR a cause ... Anemia #diagnosis #management ... #treatment #rheumatology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... cryoglobulins • Elevated ... diagnosis #types #classification ... #rheumatology #
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis

The most common causes of hyperlactatemia are usually:
Lactic Acidosis - Differential ... Causes of elevated ... / hypoxemia -> focus ... Acidosis #Elevation #Differential ... #typea #typeb #classification
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Immunosuppression • Autoimmune ... ) Classification ... Inflammatory marker elevated ... Immunohistochemical studies (to differentiate ... #management
IGG-4 RELATED DISEASE

WHAT?
 • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
• Serum IgG4 elevated ... Pancreas: Type 1 AIP (Autoimmune ... complement • Classification ... IGG4 #Diagnosis #Management ... #Rheumatology
Posterior Reversible Encephalopathy Syndrome (PRES) Overview

Clinico-Radiological Syndrome, characterized by:
 • Headache
 • Seizures
 • Altered mental
/Sepsis/Shock, Autoimmune ... Reversible course Differential ... An elevated white ... the underlying cause ... Syndrome #diagnosis #management
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Skin Disease Classification ... permanent alopecia Differential ... disease • Non-autoimmune ... rheumatologic diseases ... sediment, and elevated
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
Elevated Globulin ... Work-up of an Elevated ... Globulin Gap: • An elevated ... Cirrhosis, ETOH, autoimmune ... Gap #ProteinGap #differential
Hemophagocytic Lymphohistiocytosis (HLH)

High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
hyperinflammatory syndrome caused ... Malignancies ▪ Autoimmune ... Hyperferritinemia - Elevated ... Elevated soluble ... #Hematology #HemeOnc