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diagnosis algorithm pharmacology differential gastroenterology medications cardiology table neurology hematology rheumatology idsa infectiousdiseases guidelines pulmonary criticalcare infections nephrology clinical disease
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
vs Tumor Lysis Syndrome ... organ damage • Treatment ... Low calcium • Treatment ... - Hyperkalemia treatment ... TLS #diagnosis #management
Management of Serotonin Syndrome Identify and stop all serotoninergic medications • Avoid inadvertent Rx of serotoninergic meds
Management of Serotonin ... Syndrome Identify ... agitation and mildly elevated ... ucsdim #Serotonin #Syndrome ... #Management #treatment
Clarkson’s Disease - Capillary leak syndrome Epidemiology: Roughly 150 published cases, Median age 50 years, No sex
Capillary leak syndrome ... edema, compartment syndrome ... Hemoconcentration: elevated ... Capillary #leak #syndrome ... #diagnosis #management
Fever vs Hyperthermia Fever: • Regulated in the hypothalamic thermoregulatory center • "Set point" raised by prostaglandin
and decrease the elevated ... Neuroleptic malignant syndrome ... ; Serotonin syndrome ... comparison #diagnosis #management ... #treatment
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... >500 ng/mL • Elevated ... soluble CD25 • Elevated ... • Bicytopenia Treatment ... Lymphohistiocytosis #diagnosis #management
Hyponatremia - Diagnosis and Treatment Hyponatremia is usually caused by the inability to excrete water normally.
Diagnosis and Treatment ... 2) Is ADH elevated ... Treatment: Treatment ... demyelination syndrome ... #management #nephrology
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
CSF: Modestly elevated ... An elevated white ... epilepticus Treatment ... underlying cause • Treatment ... #diagnosis #management
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... if WBC > 5 or elevated ... Renal Failure Treatment ... APML #diagnosis #management
Stiff Person Syndrome (SPS) - Diagnosis and Management Summary Epidemiology: • Prevalence: 1-2 cases per million -
Diagnosis and Management ... with SPS have elevated ... Treatment: • ... SPS #Diagnosis #Management ... #treatment #neurology
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
(Mannitol) • Elevated ... intraocular pressure • Elevated ... disequilibrium syndrome ... irrigation • Management ... Tolvaptan) • Treatment
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