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rheumatology differential treatment algorithm hemophagocytic hepatology lymphohistiocytosis neurology symptoms workup dermatology erythematosus hemeonc liver lupus summary systemic thrombocytopenia vasculitis abnormal
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
) Pathophysiology ... • Autoimmune diseases ... : SLE+++, Adult-onset ... Still disease, ... #management #treatment
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... age, however the disease ... : HLH signs and ... #management #treatment ... #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
lymphohistiocytosis (HLH ... erythematosus [SLE ... Liver function tests ... #Diagnosis #Management ... #Hematology #Rheumatology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Initial screening test ... block • Sjogren syndrome ... #Summary #diagnosis ... #rheumatology # ... management
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Oral aphthae : SLE ... • Arthritis: SLE ... #diagnosis #management ... #signs #symptoms ... #rheumatology #
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
non-Hodgkin lymphoma SLL ... adults in the west ... Physical Exam/Signs ... cells can indicate disease ... workup #oncology #hematology
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
- Differential Diagnosis ... Vasculitides: Giant Cell ... arteritis, Cogan's Syndrome ... erythematosus (SLE ... #rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... for All Types of ... back pain) • HLA-B27 ... (to support a diagnosis ... laboratory #workup #diagnosis
Causes of Knee Effusions - Differential Diagnosis Framework Knee Effusion Red Flags: 1. Fever/Chills/Joint pain/Night sweats/Weight loss - DDX: -
- Differential Diagnosis ... arthritis - SLE ... Effusions: - Hematologic ... #differential #diagnosis ... #msk #physicalexam
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
clinical symptoms/signs ... box indicates all ... presence of metabolic syndrome ... alcohol-related liver disease ... non-alcoholic fatty liver disease
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