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Non-infective endocarditis Characteristics and Pathophysiology

By Dr. Sara Dong @swinndong via #IDFellowCase

#ID  #Infectious Diseases  #Infections
#Differential
Non-infective endocarditis ... IDFellowCase #ID #Infectious ... Diseases #Infections ... #BCNIE #CNIE #Endocarditis
Infective endocarditis - etiology and sources of infection. 
 • Native and prosthetic 
valve endocarditis
 •
Infective endocarditis ... and sources of infection ... prosthetic valve endocarditis ... • Soft tissue infections ... #Infective #Endocarditis
Causes of Antibiotic Failure - Differential Diagnosis Framework
Diagnosis:
 • Non-Infectious: Malignant, Autoimmune, Drug-related (NMS, serotonin syndrome,
Diagnosis: • Non-Infectious ... take 48 hrs for infections ... Predisposition to Infections ... lines, osteo, endocarditis ... rxn), Secondary infection
Infectious Joint Pain - Differential Diagnosis Algorithm 
Polyarticular Join Pain
 • Viral Myalgia
 • Viral Arthritis
Infectious Joint ... Disseminated Gonoccocal Infection ... • Primary HIV Infection ... • Endocarditis ... Erythema Migrans) #Infectious
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis Algorithm
Neoplasm:
• NHL
• Hodgkin's lymphoma
• Leukemia
• Solid
• Trauma Non-infectious ... Organ Specific Infection ... • Infectious ... endocarditis • ... disease Viral Infection
Fever Patterns - Differential Diagnosis Framework

Continuous Fever:
Temp > 38°C with only 1 degree fluctuation in 24
Acute bacterial endocarditis ... • Infective endocarditis ... • Gonococcal endocarditis ... Polyarteritis nodosa • Endocarditis ... Sub-acute infective endocarditis
Infective Endocarditis - Diagnosis and Management Summary
Pearls:
 - Consider non-infectious endocarditis in pts with cancer/SLE and
Infective Endocarditis ... - Consider non-infectious ... endocarditis in ... #Infective #Endocarditis
Non-Infective Endocarditis - Pathophysiology
Non-infective Endocarditis Pathophysiology:
 • Valves usually undamaged - Etiology poorly understood but thought
Non-Infective Endocarditis ... Non-infective Endocarditis ... rare Infective Endocarditis ... and failure - Infectious ... #NonInfective #Endocarditis
DENOVA score to predict endocarditis in patients with Enterococcus faecalis bacteremia
 • Duration of symptoms ≥
score to predict endocarditis ... • Origin of infection ... DENOVA #score #endocarditis
Non-Infective Endocarditis (NBTE / Marantic Endocarditis)
Non-infective endocarditis is also known as: Non-bacterial thrombotic endocarditis (NBTE), Aseptic
Non-Infective Endocarditis ... NBTE / Marantic Endocarditis ... Non-infective endocarditis ... , Marantic endocarditis ... - Infectious Diseases