851 results
Purple Urine Bag Syndrome
Chronic, indwelling catheter + bacteriuria (Providencia, Klebsiella, E.coli*) + alkaline urine
Tryptophan → Indoxyl
sulfate → Sulfatase enzyme ... Syndrome #PUBS #pathophysiology
Steroid Synthesis Pathway

(OH, hydroxy; HSD, hydroxysteroid dehydrogenase; DHEA, dehydroepiandrosterone; pink, common enzymes affecting CAH, purple –
; pink, common enzymes ... Pathway #metabolism #pathophysiology
Heme Synthesis Pathway
Enzymes
1. ALA Synthase
2. ALA Dehydratase
3. Porphobilinogen deaminase
4. UP Ill Synthase
5. UP Ill Decarboxylase
6. Coproporphyrinogen
Synthesis Pathway Enzymes ... Synthesis #Pathway #pathophysiology
Uric Acid Homeostasis
In the liver, purines are metabolized to uric acid. The last step in purine
metabolism involves an enzyme ... In animals, the enzyme ... Homeostasis #Gout #Pathophysiology
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
Angiotensin-converting enzyme ... differential #diagnosis #pathophysiology
Systemic Lupus Erythematosus: Gastrointestinal Manifestations
 - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Elevated Liver Enzymes ... Complications #pathophysiology
Inflammatory Cascade: Pathogenesis and Clinical Findings
Continued Innate Immunity
 • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
puncture holes), enzyme-mediated ... #Inflammation #pathophysiology
Complications of Measles: Pathogenesis and Clinical Findings
 • ADEM -> Fever, headache, neck stiffness, BBD, mental
elevated liver enzymes ... signs #symptoms #pathophysiology
Renin-Angiotensin-Aldosterone System (RAAS) 

The kidneys produce renin in response to low blood pressure or low plasma
angiotensin-converting enzyme ... #Pathophysiology
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings
Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
coding for the enzyme ... the amount of enzyme ... #21HydroxylaseDeficiency #21OHD #pathophysiology