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diagnosis rheumatology differential dermatology vasculitis cerebritis chronic classification cns cord cryofibrinogenemia cryoglobulins erythematosus fatigue lupus nonpalpable palpable petechiae petechial physicalexam
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Kasabach-Merritt syndrome ... Gardner-Diamond syndrome ... vasculitis/HSP • Cryoglobulinemia ... Associated - SLE, Sjogren's ... Differential #Diagnosis #hematology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... • Autoimmune diseases ... syndrome) #Cryoglobulinemia ... classification #rheumatology
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Differential Diagnosis Algorithm ... Vasculitis - Collagen disorders ... Vasculitis (lupus, RA, Sjogren's ... #Causes #dermatology
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Neoplastic / Hematologic ... Obstructive Pulmonary Disease ... Neurologic • ... • Somatization Disorder ... Chronic Fatigue Syndrome
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... Hypocomplementemia • Can cause ... Nephrogenic DI Hematologic ... #Syndrome #Rheumatology ... #Diagnosis #Management
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
Associated Disorders ... Skin necrosis • Purpura ... cryoglobulins • Negative causes ... Antiphospholipid syndrome ... #hematology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... Cerebrovascular Disease ... autoantibodies that will cause ... Erythematosus #SLE #CNS #neurology ... cerebritis #diagnosis #management
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
affects the skin, neurologic ... cognitive impairment, neurologic ... tract, and often causes ... / ANCA + MPO) Cryoglobulinemic ... vasculitis • Cogan syndrome
Spinal Cord Disorders - Differential Diagnosis Framework Spinal cord neurological lesion: Clinical findings: • Symptoms and signs below
Sarcoidosis, Behcet disease ... sclerosis - MCTD, Sjogren ... syndrome Cord ... #diagnosis #neurology ... differential #algorithm
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
body (Autoimmune disorder ... immunologically mediated diseases ... Most common • Sjogren ... Sarcoidosis • Behcet disease ... #diagnosis #management
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