8 results
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
: The ANA patterns ... ), Sjogren's Syndrome ... : Lupus (SLE), Systemic ... #ANA #patterns ... #rheumatology #diagnosis
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
ANA (Antinuclear ... • Sjögren syndrome ... connective tissue disease ... 90% • Anti-GBM disease ... #diseases
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
(ANA) - 95% - Initial ... & renal involvement ... heart block • Sjogren ... #rheumatology # ... management
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
(Granulomatous disease ... rheumatic diseases ... atherosclerotic disease ... LFT • ESR • ANA ... ) pattern: antibodies
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Decade Skin Disease ... diseases (i.e. ... (e.g. thyroid disease ... ) • Kikuchi disease
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... multisystemic disease ... associated with other diseases ... demyelinating disease ... #Syndrome #Rheumatology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Cryoglobulinemia Summary ... • They can cause ... • Autoimmune diseases ... DDX: • ANCA (Antineutrophil ... classification #rheumatology
Relapsing Polychondritis

What is it?
Recurrent inflammation of the cartilage in the body (Autoimmune disorder)

Who?
• Most frequently: 40
body (Autoimmune disorder ... immunologically mediated diseases ... as: • SLE • RA ... Sarcoidosis • Behcet disease ... Nonspecific ↑ ESR, CRP, ANA