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diagnosis differential classification erythematosus lupus systemic anca antibody antineutrophil antinuclear cerebritis cns cryoglobulinemia cryoglobulins dermatology diseases gravis hematology myasthenia myelitis
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... in drug-induced SLE ... • Sjögren syndrome ... Vasculitis: • ... #diagnosis #rheumatology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Splenomegaly - CTD (SLE ... Kasabach-Merritt syndrome ... Associated - SLE ... , Sjogren's ... #rheumatology #
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... • Autoimmune diseases ... : - 10% SLE or ... classification #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... overlaps with RA, SLE ... Hypocomplementemia • Can cause ... #Syndrome #Rheumatology ... #Diagnosis #Management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
dermatomyositis, Sjogren ... syndrome, and mixed ... Non-autoimmune rheumatologic ... APLA/LAC: • Renal ... 1, SCL-70, RNP antibodies
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
renal abnormalities ... often causes arthritis ... ) pattern: antibodies ... , and SLE) • Urinalysis ... differential #diagnosis #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... Cerebrovascular Disease ... autoantibodies that will cause ... #CNS #neurology ... #rheumatology #
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
autoimmune disorder ... Autoimmune: thyroid, Sjogren ... arthritis, SLE ... Gravis #diagnosis #management ... #neurology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
renal abnormalities ... , such as SLE, atherosclerotic ... affects the skin, neurologic ... often causes arthritis ... Differential #Diagnosis #Rheumatology
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
or Sjogren's ... Vasculitis- Heroin ... Antiamphiphysin antibodies ... Myelitis #diagnosis #management ... #neurology #differential
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