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diagnosis differential systemic dermatology erythematosus lupus sle cerebritis cns common cvid diuresis diuretics excretion fatigue hypogammaglobulinemia immunodeficiency immunology medications naildisorders
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Metabolic • Renal ... Neoplastic / Hematologic ... Neurologic • ... • Somatization Disorder ... Fatigue Syndrome
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Nail Disorders secondary ... discoloration) • Chronic ... renal failure ... • Nephrotic syndrome ... #causes
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... Distal (Type I) renal ... Nephrogenic DI Hematologic ... #Syndrome #Rheumatology ... #Diagnosis #Management
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... Cerebrovascular Disease ... autoantibodies that will cause ... #rheumatology # ... cerebritis #diagnosis #management
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
irrigation • Management ... and nephrotic syndrome ... and nephrotic syndrome ... Kidney stones caused ... specific bleeding disorders
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
dermatomyositis, Sjogren ... syndrome, and mixed ... APLA/LAC: • Renal ... with Lupus: • Chronic ... Erythematosus #Diagnosis #Rheumatology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Immunodeficiency disorder ... Autoimmunity • Chronic ... M panel Management ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
a rare chronic ... Rule out other causes ... skin disease. ... #Rheumatology # ... diagnosis #management
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
renal abnormalities ... affects the skin, neurologic ... Eosinophilia, asthma, chronic ... often causes arthritis ... Differential #Diagnosis #Rheumatology
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
body (Autoimmune disorder ... Most common • Sjogren ... Heart failure • Renal ... Polychondritis #rheumatology ... #diagnosis #management
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