7 results
Causes of Purpura or Easy Bruising in Children

Platelet count reduced, i.e. thrombocytopenia
 - Increased platelet destruction
systemic lupus erythematosus ... Meningococcal and ... infections - Vasculitis ... #Purpura #Bruising ... pediatrics #diagnosis #differential
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Clinical Features ... , Vasculitis, Purpura ... ) Blood (75%): Anemia ... #systemic #erythematosus ... #signs #symptoms
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Erythematosus) ... cutaneous lupus erythematosus ... (ACLE) • Erythematous ... cutaneous lupus erythematosus ... rashErythematous
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA) is common and ... Rarely dominate the clinical ... macules • Erythematous ... • Ulcerated, erythematous ... • Goodpasture syndrome
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
ischemia - Skin: erythematous ... mucositis - Rash ... systemic lupus erythematosus ... Presentation - Systemic Symptoms ... , and SLE) • Urinalysis
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
, such as IL-1 and ... Systemic lupus erythematosus ... rash) • Heart, ... systemic lupus erythematosus ... [SLE], AOSD) •
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... diseases, such as SLE ... ischemia • Skin: Erythematous ... , mucositis • Rash ... • Progressive symptoms