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lupus ana antinuclear hematology inflammatory macrophage muscle myelitis myopathy pathophysiology patterns primary sams sjogrens statin tafro thrombocytopenia toxicity transverse treatment
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear Visual or auditory symptoms in conjunction
BEE Syndromes - ... erythematosus ... polychondritis • Behcet ... #Syndromes #neurology ... #inflammatory #differential
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... rash • Erythematous ... lymphoma • Evans' syndrome ... Shrinking lung syndrome ... #Diagnosis #Rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... Demyelinating syndromes ... #systemic #erythematosus ... #signs #symptoms ... #diagnosis #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
lupus erythematosus ... lupus erythematosus ... Syndrome (SS), ... Arthritis, Sjögren Syndrome ... #diagnosis #differential
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
Primary Sjogren’s Syndrome ... may be seen in ... lupus erythematosus ... (SLE) Signs / ... #Signs #Symptoms
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
ischemia - Skin: erythematous ... : • Behçet Syndrome ... • Cogan Syndrome ... lupus erythematosus ... differential #diagnosis
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Syndrome (MAS) ... erythematosus ... lupus erythematosus ... #Syndrome #Diagnosis ... #Management #Hematology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Systemic disease ... syndrome (Clinical ... #Syndrome #diagnosis ... #management #signs ... #symptoms #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Differential Diagnosis ... as SLE, atherosclerotic ... ischemia • Skin: Erythematous ... • Behcet syndrome ... Diagnosis #Rheumatology
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
Guillain-Barré syndrome ... lupus erythematosus ... (SLE), polymyositis ... antisynthetase syndrome ... Lambert-Eaton myasthenic syndrome
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