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diagnosis hematology management oncology acidosis differential mds myelodysplastic syndrome aplastic cell elevation hemeonc hemophagocytic hlh hodgkins lactate lymphohistiocytosis lymphoma myelodysplasia
Lactic Acidosis - Overview and Pathophysiology Lactic acid is an endogenous substrate for gluconeogenesis, that is constantly
Lactic Acidosis ... acid is an endogenous ... with exercise/activity ... why LR does not cause ... pathophysiology #classification
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... old, ~10,000 new cases ... cytopenias (usually anemia ... only curative treatment ... #hematology #oncology
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Elevation, Lactic ... perfusion - shock->treatments ... before beginning treatment ... 30mmHg) - Severe anemia ... #typea #typeb #classification
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
for this enzyme activity ... result in severe anemia ... immune hemolytic anemia ... ThromboticThrombocytopenicPurpura #Diagnosis #Workup ... #Hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... and petechiae Causes ... propylthiouracil) - β-lactam ... Treatment: ... #oncology #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Weight loss • Anemia ... ) Classification ... Hodgkin Lymphoma Workup ... • PET scan - activity ... Hodgkin Lymphoma Treatment
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Out Secondary Causes ... factor (GCSF) treatments ... Workup: • Complete ... Syndromes #diagnosis #hematology
Stiff Person Syndrome (SPS) - Diagnosis and Management Summary Epidemiology: • Prevalence: 1-2 cases per million -
Prevalence: 1-2 cases ... and pernicious anemia ... continuous motor unit activity ... antibody that works ... Person Syndrome Treatment
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
hyperinflammatory syndrome caused ... - Cytopenias (anemia ... absent NK-cell activity ... Treatment Approach ... Diagnosis #Management #Hematology
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
CT must show no lytic ... • No CRAB - no anemia ... Bone marrow Treatment ... Oncology #Diagnosis #Workup ... #Hematology
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